![]() ![]() Long-term efficacy should be studied in future animal research.Īnimal model dorsal root ganglion stimulation neuromodulation painful diabetic polyneuropathy spinal cord stimulation. The wash-in effect of DRGS and SCS was similar, but DRGS showed a faster washout course. We conclude that conventional DRGS is as effective as SCS in reduction of PDPN-associated mechanical hypersensitivity in STZ-induced diabetic rats. Spinal cord stimulation (also called dorsal column stimulation) involves the use of low-level epidural electrical stimulation of the spinal cord dorsal columns. After cessation of stimulation (t = 60), the return of the log 10 (10 000 × 50% WT) response was significantly faster with DRGS than that of SCS (P < 0.05). Both DRGS and SCS induced a similar and complete reversal of mechanical hypersensitivity. ECAP amplitude grows linearly with stimulus current after a threshold, and a larger ECAP results in a. In the DRGS group, the log 10 (10,000 × 50% WT) increased from 4376 to 4809 at t = 15 minutes (P < 0.01) and 5042 at t = 30 minutes (P < 0.01). BackgroundThe effect of spinal cord stimulation (SCS) amplitude on the activation of dorsal column fibres has been widely studied through the recording of Evoked Compound Action Potentials (ECAPs), the sum of all action potentials elicited by an electrical stimulus applied to the fibres. The results of the experiments on these animals were compared to the results of a previous study using exactly the same model on PDPN animals selected for SCS (n = 8) (40-50 Hz, 0.19 ± 0.01 mA) and sham-SCS (n = 3). Mechanical paw withdrawal thresholds (WT, measured in grams) in response to DRGS (50 Hz, 0.18 ± 0.05 mA) were assessed with von Frey testing. ![]() Rats were assigned to DRGS (n = 11) or sham-DRGS (n = 7). Rats with a significant decrease in mechanical paw withdrawal response to von Frey filaments 4 weeks after injection were implanted with DRGS electrodes (n = 18). As in painful diabetic polyneuropathy (PDPN) pain is mostly present in the feet, we hypothesized that DRGS is more effective in relieving pain in PDPN when compared to SCS.ĭiabetes was induced in female Sprague-Dawley rats with an intraperitoneal injection of 65 mg/kg of streptozotocin (STZ n = 48). Conventional dorsal root ganglion stimulation (DRGS) is known to achieve better pain-paresthesia overlap of difficult-to-reach areas like the feet compared to dorsal column spinal cord stimulation (SCS). ![]()
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